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Oxidative Stress Induced Dysfunctions and Diseases
 

Aging

  • Accelerated aging processes 
  • Segmental progeria disorders 
  • Down's syndrome

Heart and Cardiovascular Disease

  • Atherosclerosis 
  • Adriamycin cardiotoxicity 
  • Alcohol cardiomyopathy 

Gastrointestinal Tract

  • Inflammatory & immune injury 
  • Diabetes 
  • Pancreatitis 
  • Halogenated hydrocarbon liver injury 

Eye

  • Cataractogenesis 
  • Degenerative retinal damage 
  • Macular degeneration 

Kidney

  • Autoimmune nephrotic syndromes 
  • Heavy metal nephrotoxicity 

Skin

  • Solar radiation 
  • Thermal injury 
  • Porphyria 

Nervous System Disorders

  • Hyperbaric oxygen 
  • Parkinson's disease 
  • Neuronal ceroid lipofuscinoses 
  • Alzheimer's disease 
  • Muscular dystrophy 
  • Multiple sclerosis 

Lung

  • Lung cancer (cigarette smoke) 
  • Emphysema
  • Bronchopulmonary dysphasia 
  • Asbestos carcinogenicity 

Red Blood Cells

  • Malaria ú Sickle cell anemia 
  • Fanconi's anemia 
  • Hemolytic anemia of prematurity 

Iron Overload

  • Idiopathic hemochromatosis 
  • Dietary iron overload 
  • Thalassemia 

Inflammatory-Immune injury

  • Glomerulonephritis 
  • Autoimmune disease 
  • Rheumatoid arthritis

Ischemia Reflow States

  • Stroke 
  • Myocardial infarction 

Liver

  • Alcohol-induced pathology 
  • Alcohol-induced iron overload injury
  • Hepatitis B

Other Oxidative Stress Disorders

  • Radiation-induced injuries (accidental and radiotherapy)
  • General low-grade inflammatory disorders
  • Inflamed rheumatoid joints